The nephron's ability to concentrate urine is one of the most sophisticated regulatory mechanisms in biology. Through hormonal control and osmotic gradients, kidneys can produce urine ranging from very dilute to highly concentrated, precisely matching the body's hydration needs.
đŦ Regulation Mechanisms
ADH hormone controls water reabsorption in collecting duct
Aldosterone regulates sodium reabsorption
Osmotic gradient in medulla concentrates urine
Countercurrent system multiplies concentration
Thirst mechanism coordinates with kidney function
Regulation Facts!
Your kidneys can concentrate urine to 1200 mOsm/kg - four times more concentrated than your blood plasma!
đ¯ Learning Objectives
Understand how hormones regulate urine concentration, learn about osmotic gradients, and appreciate the precision of kidney regulation.